Serum LH/FSH ratio is a more useful marker for representing the status of ovarian volume than serum AMH level in Korean women with polycystic ovary syndrome before treatment with oral contraceptives
ESC Congress Library. Chun S. May 28, 2014; 50612; A-197
Prof. Dr. Sungwook Chun
Prof. Dr. Sungwook Chun
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Objective: Combined oral contraceptives are the most common treatment for the menstrual abnormalities associated with polycystic ovary syndrome (PCOS), which is one of the most common endocrinopathies among females. The aim of this study was to investigate the relationships between basal serum hormonal parameters and ovarian ultrasound volumetric parameters in Korean women with PCOS before treatment with oral contraceptive for restoring the menstrual cycle.

Methods: A total of 90 Korean women aged 16-33 years who were newly diagnosed with PCOS and planning to receive oral contraceptives at a university hospital were included in this study. On day 3 of the menstrual cycle before treatment, measurements of serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and ultrasound evaluation of antral follicle count (AFC) and ovarian volume were performed. The correlations between hormonal parameters and ultrasound parameters were evaluated by using Pearson's correlation coefficients.

Results: Serum AMH levels and LH/FSH ratios were significantly correlated with each other (P < 0.001, γ= 0.850). Serum AMH, LH, and LH/FSH ratio were significantly correlated with AFC, but serum AMH and LH level were not significantly correlated with ovarian volume. There was a statistical significant correlation between ovarian volume and LH/FSH ratio only (P = 0.025, γ= 0.248). These results were not changed after adjusting for age and body mass index.

Conclusion: Our results suggest that basal serum LH/FSH ratio may be more useful for representing the status of ovarian volume than serum AMH level in PCOS patients before treatment with oral contraceptive, although serum AMH level is known to be the most useful marker for representing the status of ovarian reserve.
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