First urinary reproductive hormone normograms referenced to independently determined ovulation day
ESC Congress Library. Godbert S. 05/28/14; 50664; A-249 Disclosure(s): Sarah Johnson, Sarah Weddell and Sonya Godbert are employees of SPD Development Company Ltd., a fully owned subsidiary of SPD Swiss Precision Diagnostics GmbH., the manufacturers of Clearblue Pregnancy and Fertility tests. This study was funded by SPD Development Company Ltd.
Mrs. Sonya Godbert
Mrs. Sonya Godbert
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Abstract
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Objective: Normograms have been prepared based on true ovulation day for urinary lutenising hormone (LH), estrone-3-glucuronide (E3G), follicle stimulating hormone (FSH) and pregnanendiol-3-glucuronide (P3).  Although, normograms have been prepared for serum and urine reproductive hormones referenced against day of peak lutenising hormones, no study has previously referenced levels to actual day of ovulation.


Methods: 41 women with normal menstrual cycle history, completed a study where they collected daily urine samples for one complete menstrual cycle (NCT01802060).  They had frequent analysis of serum reproductive hormones and ultrasonography to observe follicle development and collapse, which allowed accurate assignment of day of ovulation.  Urinary hormones were measured using AutoDELFIA and normograms prepared centred on day of ovulation.


Results: Ovulation was observed using ultrasound/serum hormones in 40 women (1 women had anovular cycle).  Peak LH levels were seen a median of 0.5 days prior to ovulation (5th-95th centile: -1.5 to +0.5 days).  Median peak E3G levels were also 0.5 days prior to ovulation (5th-95th centile: - 2.5 to +9.5 days) and the same median peak day was seen for FSH levels
(-0.5, 5th-95th centile: -2.5 to +0.5).  P3G levels rose to peak levels a median of 7.5 days following ovulation, with a wide 5th-95th centile range of +4.5 to +10.5 days.


Conclusion:  These normograms provide the first reference for urinary reproductive hormones referenced to actual day of ovulation.

Objective: Normograms have been prepared based on true ovulation day for urinary lutenising hormone (LH), estrone-3-glucuronide (E3G), follicle stimulating hormone (FSH) and pregnanendiol-3-glucuronide (P3).  Although, normograms have been prepared for serum and urine reproductive hormones referenced against day of peak lutenising hormones, no study has previously referenced levels to actual day of ovulation.


Methods: 41 women with normal menstrual cycle history, completed a study where they collected daily urine samples for one complete menstrual cycle (NCT01802060).  They had frequent analysis of serum reproductive hormones and ultrasonography to observe follicle development and collapse, which allowed accurate assignment of day of ovulation.  Urinary hormones were measured using AutoDELFIA and normograms prepared centred on day of ovulation.


Results: Ovulation was observed using ultrasound/serum hormones in 40 women (1 women had anovular cycle).  Peak LH levels were seen a median of 0.5 days prior to ovulation (5th-95th centile: -1.5 to +0.5 days).  Median peak E3G levels were also 0.5 days prior to ovulation (5th-95th centile: - 2.5 to +9.5 days) and the same median peak day was seen for FSH levels
(-0.5, 5th-95th centile: -2.5 to +0.5).  P3G levels rose to peak levels a median of 7.5 days following ovulation, with a wide 5th-95th centile range of +4.5 to +10.5 days.


Conclusion:  These normograms provide the first reference for urinary reproductive hormones referenced to actual day of ovulation.

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