Novel Targeted Drug Delivery to the Cervix and Vagina by a Barrier Contraceptives Device: A Pilot Study for Proof the Concept
ESC Congress Library. Shihata A. May 4, 2016; 127014; A-188
Dr. Alfred Shihata
Dr. Alfred Shihata
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Abstract
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Background The vast majority of Sexually Transmitted Infections (STIs) and cervicitis are treated with drugs that come with potential systemic side effects. The few infections that are treated topically require gels or creams to be inserted into the vagina by traditional vaginal applicators. The vagina expels these gels and creams shortly after the insertion, rendering them less effective.

 

Objectives

 

A) To test a barrier contraceptive device’s potential to deliver drugs topically for the treatment and prevention of STIs such as HPV, HIV, Gonorrhea, and Chlamydia.

 

B) To eliminate the need for destructive surgery on the cervix when treating HPV.

 

C) To enhance the safety and efficacy of topical treatments to the cervix and vagina.

 

Methods: We applied a stained vaginal gel over the cervix and vagina, using a vaginal applicator in 10 women. We applied the same stained gel with a barrier contraceptive device in 10 other women. We then compared the retention of the stained gel by photographing the cervix and vagina for the presence of the stained gel at 6, 12 and 24 hours after application.

 

Results: The stained gel was present over the cervix 24 hours after application with the contraceptive barrier device. It was absent after 6 hours when applied with the vaginal applicator.

 

Conclusion: This pilot study has demonstrated that gels or creams inserted into the vagina using the barrier contraceptive device have much better retention. Thus, more prolonged contact with an offending pathogenic agent would be anticipated.

 

This study may lead to a topical method for the prevention and treatment of STIs, including HPV and HIV infections. Topical treatment may also lead to better safety and higher efficacy than systemic treatment.

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