Expression of progesterone-membrane bound receptor may predict the risk and prognosis of breast cancer like or even better compared to other prognosis parameters
ESC Congress Library. Mueck A. May 4, 2016; 127056; A-230
Alfred Mueck
Alfred Mueck
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Abstract
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Objectives: Progesterone receptor membrane component 1(PGRMC1) has been shown to be higher expressed in breast cancer compared to normal tissue and if present, may increase the risk of breast cancer in women getting hormone therapy or contraceptives (Editorial Stanczyk F. Menopause 2011; 18: 833-834). In a first clinical study in patients after breast cancer we investigated if this marker also could predict the further prognosis of those patients comparing with other already well known parameters.
Design & methods: Expression of PGRMC1 was analyzed by immunohistochemical staining of tissues from 69 breast cancer patients, and correlated with various clinic-pathological characteristics such as larger tumor size, lymph node metastasis and clinical outcome like disease free survival and overall survival time.
Results: Overexpression of PGRMC1 correlated with larger tumor size and lymph node metastasis. The Kaplan-Meier survival curves revealed that PGRMC1 overexpression is associated with poor disease free and overall survival, both in breast cancer patients with ER (estrogen receptor) positive and negative tumors.
Conclusions: PGRMC1 overexpression is significantly associated with aggressive phenotypes and poor prognosis of breast cancer. These findings support the possible role of PGRMC1 not only to predict the risk using hormones in therapy and contraception but also as a prognostic biomarker in ER-positive and negative breast cancer.

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