Study on Contraceptive Potential of Terminalia chebula (Retz.) in Male Albino Mice
ESC Congress Library. Gupta P. May 10, 2018; 208074; ESC34
Prof. Prakash Chandra Gupta
Prof. Prakash Chandra Gupta
Login now to access Regular content available to all registered users.

You may also access this content "anytime, anywhere" with the Free MULTILEARNING App for iOS and Android
Rate & Comment (0)
Abstract Development of an orally active, safe, reversible and effective male contraceptive of plant origin has always been a matter of great attention for researchers. In the present investigation, drugs prepared from the bark (extracted in acetone, methanol, 50 % ethanol, cold and hot aqueous solvents) of Terminalia chebula Retz., were administered (300 mg/kg body weight/day for 28 days) orally to the Parkes (P) strain male albino mice, and alterations in reproductive organs, sperm and fertility parameters were investigated. Toxicological studies were also carried out. The treatments caused non-uniform histological alterations in the testis and epididymis with variations among different treated groups and individuals. Mice treated with cold and hot aqueous extracts of the plant showed more severe histological alterations in their testes and epididymes compared to those in other treated groups and controls. Sperm parameters, however, were adversely affected in all the extracts-treated mice compared to controls. Libido was not affected, but fertility reduced markedly in aqueous extracts-treated males compared to controls. Further, histology of liver, kidney, adrenal gland, and spleen, serum levels of ALT, AST and creatinine, and haematological parameters showed no alterations in extracts-treated mice. The results of the present investigation suggest that the aqueous bark extracts of Terminalia chebula caused suppression of the spermatogenesis and fertility in males more efficiently than the other extracts of the plant, and therefore, might be useful in the development of a novel herbal male contraceptive. 
    This eLearning portal is powered by:
    This eLearning portal is powered by MULTIEPORTAL
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.

Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.

Save Settings