Study on Contraceptive Potential of Terminalia chebula (Retz.) in Male Albino Mice
ESC Congress Library. Gupta P. May 10, 2018; 208074; ESC34
Prof. Prakash Chandra Gupta
Prof. Prakash Chandra Gupta
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Abstract
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Abstract Development of an orally active, safe, reversible and effective male contraceptive of plant origin has always been a matter of great attention for researchers. In the present investigation, drugs prepared from the bark (extracted in acetone, methanol, 50 % ethanol, cold and hot aqueous solvents) of Terminalia chebula Retz., were administered (300 mg/kg body weight/day for 28 days) orally to the Parkes (P) strain male albino mice, and alterations in reproductive organs, sperm and fertility parameters were investigated. Toxicological studies were also carried out. The treatments caused non-uniform histological alterations in the testis and epididymis with variations among different treated groups and individuals. Mice treated with cold and hot aqueous extracts of the plant showed more severe histological alterations in their testes and epididymes compared to those in other treated groups and controls. Sperm parameters, however, were adversely affected in all the extracts-treated mice compared to controls. Libido was not affected, but fertility reduced markedly in aqueous extracts-treated males compared to controls. Further, histology of liver, kidney, adrenal gland, and spleen, serum levels of ALT, AST and creatinine, and haematological parameters showed no alterations in extracts-treated mice. The results of the present investigation suggest that the aqueous bark extracts of Terminalia chebula caused suppression of the spermatogenesis and fertility in males more efficiently than the other extracts of the plant, and therefore, might be useful in the development of a novel herbal male contraceptive. 
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