CHANGES OF THE MAIN INDICATORS OF IRON METABOLISM IN WOMEN USING ORAL COTRACEPTIVES
ESC Congress Library. Babadjanova G. May 10, 2018; 208180; ESC281
Guldjahan Babadjanova
Guldjahan Babadjanova
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Abstract
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The most observable effect of oral contraception (OC) is the reduction of menstrual blood loss, which influences into the iron metabolism that occurs in 65-75% of women who use them. The aim of the study was determination of the effect from using of OC into the main parameters of iron metabolism and his supplies by measuring serum iron, serum ferritin, transferrin, and iron binding capacity of serum in women of reproductive age using OC. Materials and methods: A comparative research of serum ferritin and other indicators of the iron metabolism was carried out in 40 women who took OC for two or more years and 20 women who has never taken OC. Results. All women in the OC user group took various combined oral contraceptives. In this group the duration of menstrual bleeding was significantly less, and the continuance of the menstrual cycle was shorter also. All parameters are significantly higher for a group of OC users (p < 0 .0015), except for the percentage of transferrin saturation that did not differ significantly. The average serum ferritin in OC users is 14.1 ng / ml greater or more than 50% higher than the mean of control group. The average serum ferritin level for OC users was 36.5 ± 21.49 ng / ml, and the mean of control group level was 22.4 + or -16.01 ng / ml, which is significantly different at P0.001. Serum transferrin, serum iron level, MCH and MCHC were significantly higher in the OC user group. Significantly lower levels of erythrocytes and hematocrit were found in women using OC, while other parameters, hemoglobin level, MCV and percentage transferrin saturation did not differ significantly. There were no significant differences in the characteristics of women and eating habits, except for differences in the characteristics of the menstrual cycle and higher iron content in food in OC users.  Studies have shown that under the influence of sex steroids during taking OC occurs induction and release of ferritin from the liver into the blood. A higher serum ferritin level in women using OC may be associated with various possible effects of OC: 1) decreased menstrual blood loss; 2) hormonal stimulation of apoferritin biosynthesis in the liver; and / or 3) an increase in the amount of iron absorption. Conclusion: in the organism of a woman who uses OC, higher iron reserves are noted, than in women of the control group who did not take OC. 
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