Contraception in renal transplanted women: is the injectable contraceptive a safe option?
ESC Congress Library. Giovanelli S. May 10, 2018; 208232
Silvana Giovanelli
Silvana Giovanelli
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Abstract
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Objectives: evaluate clinical parameters and basic laboratory tests in renal transplanted women using the depot medroxyprogesterone acetate (DPMA 150mg) as a contraceptive method. Compare the findings with other renal transplanted patients using condom. Material and methods: retrospective cohort study conducted between October 1, 2014 to July 30, 2016 in renal transplanted patients enrolled in the family planning unit at Federal University of São Paulo, who are in use of DPMA or condom. The survey data included age, body mass index,  gravidity/parity, contraceptive use and time of transplant. Were also analyzed clinical parameters (weight and blood pressure) and laboratory tests (blood count and creatinine) in two moments: unit admission and six months later.  The statistical tests include Student t test for independent variables, ANOVA for averages over time and linear regression to compare effects of each method in different variables (blood pressure, creatinine, blood count) along the two moments of evaluation. The study was approved by the local Ethics Committee. RESULTS: 136 renal transplanted women was admitted in the analyzed period. During follow-up, 46 patients (33,8%) did not return, 8 has chosen intra-uterine devices, 12 combined oral contraceptives and 6 progestin-only pills. 30 women are in use of depot medroxyprogesterone acetate and other 20 condom, who were included for the study. The analysis of clinical parameters (body mass index, gravidity/parity and time of transplant) has showed no statistical difference between group profiles, except on age (p=0,03). The analysis of contraceptive effects has showed no difference in blood pressure, weight gain, creatinine and blood count between groups. CONCLUSIONS: The medical literature shows few studies about contraception in renal transplanted patients.  In our first analysis the use of DPMA did not change weight gain, blood count, creatinine and blood pressure compared to condom users. Therefore, the 3-month injectable can be a safe and effective option for this patients.
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