Hemostasiological status in females with recurrent miscarriage after usage of combined oral contraceptives
ESC Congress Library. Kazhyna M. May 11, 2018; 208265; ESC229
Prof. Maria Kazhyna
Prof. Maria Kazhyna
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Abstract
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Combined oral contraceptives (COC) in females with recurrent miscarriage (RM) are used for rehabilitation after pregnancy loss.  The main side effect of COC is trombosis. Objective. To estimate hemostasiological parameters in females with RM who use COC v/s those who do not use.   Design and methods. 61 women with RM at the age from 21 to 41 were divided into 2 groups: 1 (n=22) use COC (Ме - 4,5 months); 2 (n=39) - non-use COC.   Examination: blood examination, APTT, fibrinogen, D-dimer, rotational thromboelastometry (ROTEM) were used for integral evaluation of the system of hemostasis.  Statistical data processing was conducted with the help of the application software package STATISTICA 10.0 (SN AXAR207F394425FA-Q). Results.  Analysis of  EXTEM, INTEM and FIBTEM ROTEM test results show  the significant difference between groups. Women from group II showed  chronometric structural hypercoagulation (ROTEM): lower CT, CFT indices and higher А5, А15, А20, А30, MCF and ALP indices.  Comprehensive evaluation of hemostasis shows that women who took  COC for rehabilitation purposes after miscarriage have no activation of  hemostatic system despite the  thrombogenic activity of drugs. Women who didn't take COC are likely to be prone to chronometric structural hypercoagulation. Conclusions.  According to data obtained  the activation of thrombosis among this category of women happens not only due to activation of external pathway of blood clotting but also due to internal one and mainly due to changes of qualitative fibrinogen characteristics.  
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